Wasabi Science is all about bioactive Isothiocyanates, notably 6-MSITC

6-Methylsulfinylhexyl Isothiocyanate (6-MSITC) is a fascinating bioactive isothiocyanate compound most commonly found in real wasabi, traditionally used in Japanese cuisine.

Wasabi is a member of the Brassicaceae (cruciferae) family, which includes other well-known plants like mustard, horseradish, cabbage, broccoli, and less known members like moringa.  

The Magic Behind Wasabi’s Bioactive Compounds

What makes the 6-MSITC isolate of Isothiocyanates so incredibly interesting is how it's magically created in a literal wisp of time under unimaginable time constraints...

The creation of 6-MSITC happens through a kind of biochemical “dance” that occurs.

Within the cells of the wasabi plant, there are compounds called glucosinolates, which stay dormant until something like a bite or a cut disrupts the plant’s cells.

When this happens, an enzyme called myrosinase gets to work, breaking down the glucosinolates into various bioactive compounds—one of which is 6-MSITC. 

This reaction is responsible for wasabi’s unique heat and sharp flavor, which can feel intense but is also where much of the health benefit comes from.

This transformation is fast and fleeting...

6-MSITC peaks in potency when fresh wasabi is grated or mixed with water.

It's a bit like a culinary performance that unfolds quickly and then fades, leaving a spicy, sharp sensation and potentially powerful health benefits.

Health Benefits of 6-MSITC

  • Cognitive Support: Studies have shown that 6-MSITC might help improve memory, particularly working memory and episodic memory—both crucial for our day-to-day cognitive tasks.

  • Neuroprotection: There’s also evidence suggesting that it could protect brain cells, particularly those critical for movement, and help reduce neuroinflammation. This could be important for conditions like Parkinson’s disease, where protecting those neurons is key.

  • Anti-inflammatory Effects: 6-MSITC acts as a potent anti-inflammatory. This is important for reducing the risk of chronic diseases such as heart disease, cancer, and metabolic syndrome, where inflammation plays a major role in disease progression.

  • Antioxidant Power: 6-MSITC also helps fight oxidative stress, which can damage cells. This is particularly useful for managing conditions like diabetes and obesity, as it helps protect important cells like those in the pancreas.

Why Wasabi’s Chemistry is So Fleeting

The process of producing 6-MSITC in wasabi is tied to its volatile nature. As wasabi’s tissues are damaged (like when it’s grated), the reaction that produces 6-MSITC occurs quickly but then fades just as fast. The isothiocyanates formed in this process are chemically unstable and vaporize at room temperature, meaning the intense flavor dissipates quickly. This fleeting experience is part of why fresh wasabi is best used right away, both for flavor and for getting the most benefit out of its bioactive compounds.

Where You Can Find 6-MSITC

While wasabi is the richest source of this compound, you can also get some measure of it from other cruciferous vegetables like broccoli, cabbage, and Brussels sprouts. Those don’t pack the same punch as wasabi, but they still contribute beneficial glucosinolates that can be converted into bioactive isothiocyanates under the right conditions.

Safety and Considerations

6-MSITC is considered safe when consumed as part of food, especially in traditional amounts (like in wasabi). However, if you’re thinking about taking supplements or consuming higher doses, it’s a good idea to check with a healthcare professional—particularly if you have thyroid issues or are on blood-thinning medications.

Conclusion

In short, 6-MSITC is one of those amazing compounds with multiple health benefits, from supporting brain health and reducing inflammation to potentially protecting against cancer and oxidative stress. Whether it’s in fresh wasabi or cruciferous veggies, adding isothiocyanates including 6-MSITC to your diet could provide some impressive health perks. And thanks to the fascinating, fleeting chemistry of wasabi, know when you eat it you’re not just getting a spicy kick but also a little extra boost for your well-being.