Let’s dive deeper into the science behind Wasabi and the bio-active compound 6-MSITC

For centuries, Japanese culture has valued wasabi (Eutrema japonicum syn. Wasabia japonica) not only as a flavorful condiment but also for its nutraceutical benefits. In recent decades, global interest in this natural superfood has surged, with research exploring its potential to support healthy aging, promote homeostasis, and enhance overall well-being. Wasabi’s rhizome (root) contains rich levels of required precursors to produce  6-methylsulfinylhexyl isothiocyanate, a bioactive compound renowned for its anti-inflammatory and antioxidant and nootropic properties.

What makes the 6-MSITC isolate of isothiocyanates (ITC’s) so incredibly interesting is how it's often created and exists in mere moments of time.  6-MSITC happens through a biochemical reaction between compounds residing in separate cells of the wasabi plant. Compounds called Glucosinolates, in the case of wasabi, Sinigrin, stay dormant until something like a bite or a cut disrupts the plant’s cells. When this happens, an enzyme called Myrosinase (chilling in separate cells) gets to work, breaking down the Glucosinolates into various bioactive compounds—one of which is 6-MSITC.

This transformation can be time sensitive. 6-MSITC and other ITC’s  peaks in potency when fresh wasabi is grated or, in the case of powders mixed with water. In the case of wasabi powder, the 6-MSITC compound is released once it is ingested and manifests itself in the gastrointestinal track. 

It's a bit like a culinary performance that unfolds quickly and then fades, leaving a spicy, sharp sensation and potentially powerful health benefits.

Health Benefits of 6-MSITC

Cognitive Support: Studies have shown that 6-MSITC might help improve memory, particularly working memory and episodic memory—both crucial for our day-to-day cognitive tasks.

Neuroprotection: There’s also evidence suggesting that it could protect brain cells, particularly those critical for movement, and help reduce neuroinflammation. This could be important for conditions like Parkinson’s disease, where protecting those neurons is key.

Anti-inflammatory Effects: 6-MSITC acts as a potent anti-inflammatory. This is important for reducing the risk of chronic diseases such as heart disease, cancer, and metabolic syndrome, where inflammation plays a major role in disease progression.

Antioxidant Power: 6-MSITC also helps fight oxidative stress, which can damage cells. This is particularly useful for managing conditions like diabetes and obesity, as it helps protect important cells like those in the pancreas.

Where You Can Find 6-MSITC

Wasabia japonica is a cruciferous vegetable in the vegetable family Brassicaceae, which includes vegetables like broccoli, cabbage and Brussel sprouts. It is recognized that they too contain beneficial Glucosinolates, however to a lesser degree that what is found in the rhizomes (roots) of authentic wasabi plants.

Safety and Considerations

6-MSITC is considered safe when consumed as part of food, especially in traditional amounts (like in wasabi). However, if you’re thinking about taking supplements or consuming higher doses, it’s a good idea to check with a healthcare professional—particularly if you have thyroid issues or are on blood-thinning medications.

Conclusion

The world-wide attention that Wasabia japonica is receiving is truly warranted. Recent studies have identified the positive effects that these bioactive compounds can have on our well-being. We are excited to be in this community which is discovering the characteristics of a plant whose value has been revered for centuries.